I think as you go from the easy stuff on the table, manually resisted, all the way to that continuum of getting back to their sport, as you start to add the velocity piece and monitoring how they do, I think you have to consider I guess the location and the velocity are two factors that I take into account pretty often
The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation
These labs allow detection of pre-existing contraindications (impaired kidney or liver function, subclinical thyroid dysfunction) and provide reference values for interval monitoring during the protocol
Pharmacol Rev 43:109142 Nordt SP, Williams SR, Turchen S, Manoguerra A, Smith D, Clark RF (1996) Hypermagnesemia following an acute ingestion of Epsom salt in a patient with normal renal function